Related Experiment Video
Updated: Aug 12, 2026
Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Blood-conservation techniques for coronary-artery bypass surgery at a private hospital
M J Davies1, J Picken, B F Buxton
1Epworth Hospital, Richmond, VIC.
Insights
This study on coronary-artery bypass surgery found no difference in homologous blood use across graft types. However, bilateral internal-mammary-artery grafts led to greater postoperative blood loss.
Area of Science:
- Cardiovascular Surgery
- Transfusion Medicine
Background:
- Coronary-artery bypass surgery (CABS) often requires blood transfusions.
- Minimizing homologous blood use is crucial for patient safety and resource management.
Purpose of the Study:
- To evaluate homologous blood utilization in primary CABS.
- To compare blood conservation strategies and identify factors influencing blood loss.
Main Methods:
- Prospective study of 100 CABS patients.
- Utilized normovolaemic haemodilution, autologous blood collection, intraoperative blood scavenging, and postoperative mediastinal drainage collection.
- Categorized patients by grafting strategy: saphenous vein only, single internal mammary artery (IMA) with vein grafts, and bilateral IMA with vein grafts.
Main Results:
- Mean homologous blood use was 1.3 units, with 0.2 units of fresh-frozen plasma and 0.8 units of platelets.
- No significant difference in homologous blood utilization was observed among the three grafting strategies.
- Patients receiving bilateral IMA grafts experienced greater postoperative blood loss compared to other groups.
Conclusions:
- Grafting strategy does not significantly impact homologous blood requirements in primary CABS.
- Bilateral IMA grafting is associated with increased postoperative blood loss, warranting further investigation.
- Preoperative aspirin or NSAID use did not affect homologous blood utilization but was linked to increased postoperative blood loss.
Abstract:
The utilization of homologous blood and blood products was recorded in 100 consecutive patients who underwent primary coronary-artery bypass surgery. Nine patients underwent saphenous-vein grafts only, 55 patients underwent a single internal-mammary-artery graft that was supplemented by vein grafts and 36 patients underwent bilateral internal-mammary-artery grafts and vein grafts. All patients underwent normovolaemic haemodilution, and autologous blood was collected before bypass surgery. Residual blood was collected from the cardiopulmonary bypass machine and was washed and concentrated in a cell processor, and blood also was scavenged postoperatively from the mediastinal drainage tubes as methods to conserve blood. The mean (+/- SD) utilization of homologous blood was 1.3 +/- 1.5 units with 0.2 +/- 0.7 units of fresh-frozen plasma being used, and 0.8 +/- 2.1 units of platelets being used. The utilization of homologous blood was not different among the three different methods of coronary-artery bypass surgery, but patients who underwent bilateral internal-mammary-artery grafts suffered a greater postoperative loss of blood than did those patients who underwent saphenous-vein grafts or single internal-mammary-artery grafts. A comparison of patients who were taking aspirin or a non-steroidal anti-inflammatory drug preoperatively with those patients who were not showed no difference in the utilization of homologous blood but a statistically-significant difference was found in the loss of blood postoperatively.
More Related Videos
09:54Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
05:25Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023