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Novel activity-based probes for N-acylethanolamine acid amidase
Rita Petracca1, Elisa Romeo, Marc P Baggelaar
1School of Chemistry and Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, The University of Dublin, Dublin 2, Ireland.
Chemical Communications (Cambridge, England)
|October 17, 2017
Abstract:
The cysteine hydrolase, N-acylethanolamine acid amidase (NAAA) is a promising target for analgesic and anti-inflammatory drugs. Here, we describe the development of two unprecedented NAAA-reactive activity-based probes as research tools for application in the discovery of new inhibitors and for the in-depth characterization of NAAA in its cellular environment.