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ComplexViewer: visualization of curated macromolecular complexes.

Colin W Combe1, Marine Dumousseau Sivade2, Henning Hermjakob2

  • 1Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9?3BF, UK.

Bioinformatics (Oxford, England)
|October 17, 2017
PubMed
Summary

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This summary is machine-generated.

ComplexViewer visualizes protein interactions beyond simple pairs, displaying complex biological assemblies. This tool aids in understanding molecular interactions by showing multi-protein complexes and their binding regions.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Proteins often function in large complexes, not just binary interactions.
  • Current network visualizations typically represent only pairwise protein associations.
  • Visualizing complex biological assemblies is crucial for understanding cellular functions.

Purpose of the Study:

  • To introduce ComplexViewer, a novel visualization tool.
  • To enable the visualization of multi-protein interactions and complexes.
  • To display known binding regions within these complexes.

Main Methods:

  • ComplexViewer is a JavaScript-based web tool utilizing Scalable Vector Graphics and D3.js.
  • It visualizes interactions involving more than two participants.

Related Experiment Videos

  • Binding regions can be displayed within the context of larger complexes.

    • Main Results:

    • ComplexViewer effectively visualizes complex biological assemblies.
    • It avoids the need to deconstruct complexes into numerous binary interactions.
    • The tool integrates information on binding regions.

    Conclusions:

    • ComplexViewer offers a more accurate representation of protein interactions.
    • It enhances the understanding of complex biological systems.
    • The tool is freely available for use and modification.