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Updated: Feb 20, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus
Volker Spindler1, Rüdiger Eming2, Enno Schmidt3
1Institute of Anatomy and Cell Biology, Ludwig-Maximilians-Universität, Munich, Germany.
Abstract:
The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.
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