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Immune engineering: from systems immunology to engineering immunity.

Ning Jiang1,2

  • 1Department of Biomedical engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.

Current Opinion in Biomedical Engineering
|October 18, 2017
PubMed
Summary
This summary is machine-generated.

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This review explores immune engineering, from early vaccines to modern CAR-T cell therapies. Advances in systems biology and high-throughput technologies enhance our understanding of adaptive immunity.

Area of Science:

  • Immunology
  • Biomedical Engineering
  • Systems Biology

Background:

  • The smallpox vaccine pioneered immunity engineering.
  • Chimeric antigen receptor T cells (CAR-T cells) show significant cancer therapy potential.
  • Diverse immune cells and molecules are targets for immune enhancement.

Purpose of the Study:

  • To review recent advancements in systems biology and adaptive immunity engineering.
  • To highlight the role of high-throughput technologies in understanding immunity.
  • To connect historical immune engineering with current therapeutic strategies.

Main Methods:

  • Review of literature on immune engineering and systems biology.
  • Analysis of high-throughput technologies like immune repertoire sequencing.

Related Experiment Videos

  • Integration of engineering principles with immunological research.

    • Main Results:

    • Significant progress in engineering dendritic cells, NK cells, T cells, antibodies, and cytokines.
    • Systems-level understanding of human immunity is improving through advanced technologies.
    • Biomedical engineers are crucial in developing these high-throughput tools.

    Conclusions:

    • Immune engineering, boosted by systems biology and technology, offers vast therapeutic potential.
    • Understanding adaptive immunity at a systems level is key to future breakthroughs.
    • The field continues to evolve from historical interventions to sophisticated cellular therapies.