Related Experiment Video

Updated: Feb 20, 2026

Author Spotlight: Enhancing Coronary Artery Revascularization
05:25

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

1.3K

[Factors for the development of persistent postoperative cognitive dysfunction in patients undergoing coronary artery

O A Trubnikova1, I V Tarasova1, O V Maleva1

  • 1Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.

Terapevticheskii Arkhiv
|October 18, 2017
PubMed

Insights

High baseline cognition, early cognitive decline, poor treatment adherence, and carotid artery stenosis predict persistent postoperative cognitive dysfunction after coronary artery bypass surgery. These factors highlight the multifactorial nature of this condition.

Area of Science:

  • Cardiology
  • Neurology
  • Surgical Outcomes

Background:

  • Coronary artery bypass surgery (CABS) using extracorporeal circulation (EC) is a common procedure for coronary heart disease (CHD).
  • Postoperative cognitive dysfunction (POCD) is a recognized complication, with persistent POCD posing a significant long-term concern for patients.

Purpose of the Study:

  • To identify key factors predicting the development of persistent POCD in patients undergoing CABS under EC.
  • To analyze the multifactorial contributors to long-term cognitive impairment following cardiac surgery.

Main Methods:

  • A cohort of 257 male patients (aged 45-69) with CHD undergoing elective CABS under EC were assessed.
  • Neuropsychological testing was performed preoperatively, early postoperatively (7-14 days), and at 1-year follow-up.
  • Persistent POCD was defined as a 20% decline in cognitive domains at 1 year; binary logistic regression identified risk factors.

Main Results:

  • High baseline cognitive status was associated with an increased risk of persistent POCD.
  • Early POCD, low adherence to treatment regimens, and progressive carotid artery stenosis were significant predictors.
  • These factors collectively predicted persistent POCD with 85% probability at 1 year post-surgery.

Conclusions:

  • Persistent POCD following CABS under EC is multifactorial.
  • Preoperative cognitive status, early postoperative cognitive changes, treatment adherence, and carotid artery health are crucial determinants.
Abstract

Keywords:
carotid artery stenosiscoronary artery bypass surgerydegree of adherence to the prescribed treatment regimenextracorporeal circulationpostoperative cognitive dysfunction

More Related Videos

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

10.0K
A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats09:54

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats

Published on: March 23, 2018

8.4K

Related Concept Videos

Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
389
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
431
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
500
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
315
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
320
Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
382