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Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children
Tony Chao1,1,1, Craig Porter1,1, David N Herndon1,1,1
1Metabolism Unit, Shriners Hospitals for Children, Galveston, TX.
Medicine and Science in Sports and Exercise
|October 18, 2017
Summary
Rehabilitative exercise training (RET) combined with oxandrolone and propranolol (Oxprop) therapy significantly enhanced muscle strength and improved protein turnover in severely burned children. This combination therapy offers greater benefits than RET alone for pediatric burn recovery.
Area of Science:
- Pediatric Medicine
- Burn Rehabilitation
- Metabolic Disorders
Background:
- Severe burns cause prolonged hypermetabolism and muscle breakdown in children.
- Rehabilitative exercise training (RET) aids muscle recovery, but optimal therapeutic combinations are unknown.
Purpose of the Study:
- To investigate if RET combined with oxandrolone and propranolol (Oxprop) improves muscle mass, strength, cardiorespiratory fitness, and protein turnover in severely burned children compared to placebo.
Main Methods:
- A placebo-controlled randomized trial involving 42 severely burned children (7-17 years).
- Patients received either Oxprop or placebo, followed by standardized RET post-discharge.
- Measurements included muscle strength, power, V˙O2peak, body composition, and protein turnover rates (PRE and POST RET).
Main Results:
- Both groups showed improvements in muscle strength, power, lean body mass, and V˙O2peak with RET.
- The Oxprop group demonstrated significantly greater increases in strength and power compared to the placebo group.
- Oxprop therapy led to a higher fractional synthetic rate, improving protein net balance post-treatment.
Conclusions:
- RET is effective for improving body composition, muscle function, and fitness in pediatric burn survivors.
- Oxprop therapy significantly augments RET-induced improvements in muscle strength, power, and protein metabolism.
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