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U-47700: A Not So New Opioid.

Timothy P Rohrig1, Samuel A Miller1, Tyson R Baird1

  • 1Regional Forensic Science Center, 1109 N. Minneapolis, Wichita, KS 67214,USA.

Journal of Analytical Toxicology
|October 18, 2017
PubMed
Summary
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This case report details the first death in Kansas solely from U-47700 intoxication. This potent synthetic opioid, U-47700, was detected in various tissues after initial opioid screens were negative.

Area of Science:

  • Forensic Toxicology
  • Pharmacology
  • Clinical Chemistry

Background:

  • U-47700, a selective mu-opioid agonist, was developed in the 1970s.
  • It has recently resurfaced in illicit drug markets, often mis-sold as other substances.
  • Fatalities involving U-47700 are increasingly reported, frequently in poly-intoxication cases.

Observation:

  • A case report of the first fatality in south-central Kansas attributed solely to U-47700 intoxication.
  • A 26-year-old male was found deceased with drug paraphernalia; autopsy suggested opioid overdose.
  • Standard opioid immunoassay screening was negative, necessitating advanced toxicological analysis.

Findings:

  • U-47700 was identified via GC/MS and GC-NPD comprehensive alkaloid screening.

Related Experiment Videos

  • Quantitative analysis using GC-NPD revealed significant U-47700 concentrations in multiple specimens.
  • Detected levels included: heart blood 0.26 mg/L, femoral blood 0.40 mg/L, vitreous fluid 0.09 mg/L, brain 0.38 mg/kg, liver 0.28 mg/kg, and urine 4.6 mg/L.

    • Implications:

    • Highlights the challenges in detecting novel synthetic opioids like U-47700 with standard screening methods.
    • Underscores the critical role of comprehensive toxicological analysis in forensic investigations.
    • Emphasizes the public health risk posed by the illicit availability and potent effects of U-47700.