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Related Experiment Videos

Resting-state functional connectivity in combat veterans suffering from impulsive aggression.

Tim Varkevisser1,2,3, Thomas E Gladwin1,2, Lieke Heesink1,2,3

  • 1University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Social Cognitive and Affective Neuroscience
|October 18, 2017
PubMed
Summary

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Combat veterans with impulsive aggression show reduced brain connectivity between the amygdala and prefrontal cortex. This suggests impaired emotional regulation may underlie aggression after deployment.

Area of Science:

  • Neuroscience
  • Military Psychology
  • Brain Imaging

Background:

  • Impulsive aggression is prevalent in military personnel post-deployment.
  • This aggression may stem from impaired top-down regulation of the amygdala by prefrontal areas.

Purpose of the Study:

  • To investigate the hypothesis of impaired prefrontal-amygdala regulation in combat veterans.
  • To explore resting-state functional connectivity in impulsively aggressive combat veterans.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) was used.
  • Functional connectivity analyses focused on seed regions: basolateral amygdala (BLA), centromedial amygdala, anterior cingulate cortex (ACC), and anterior insular cortex (AIC).
  • Exploratory cluster analyses identified group differences.
Keywords:
DLPFCamygdalafunctional connectivityimpulsive aggressionneuroimaging

Related Experiment Videos

Main Results:

  • Reduced functional connectivity between the bilateral basolateral amygdala (BLA) and left dorsolateral prefrontal cortex was observed in the impulsive aggression group.
  • Significant group differences in functional connectivity were also found between the bilateral ACC and left cuneus, and the left AIC and right temporal pole.

Conclusions:

  • Combat-related impulsive aggression is associated with weakened functional connectivity between the amygdala and prefrontal regions, even without emotional stimuli.
  • Altered connectivity in ACC-cuneus and AIC-temporal pole circuits may relate to vigilance and negative memory associations in impulsive aggression.