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Updated: Feb 20, 2026

Fluorescence detection methods for microfluidic droplet platforms

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Photonic integration platform with pump free microfluidics.

R Thomas, A Harrison, D Barrow

|October 19, 2017

Summary

This study presents a chip-scale photonic fluid measurement system using 3D capillary microfluidics. It enables accurate particle velocity and size detection without external pumps, advancing microfluidic sensing technology.

Area of Science:

Photonics
Microfluidics
Biotechnology

Background:

Traditional fluid analysis often requires bulky external equipment.
Integrating sensing components onto a single chip presents a significant challenge.
Existing methods may lack precision in determining particle behavior within microfluidic channels.

Purpose of the Study:

To demonstrate a true chip-scale photonic measurement system for fluids.
To develop a method for measuring local particle velocity without external pumps.
To enable scalable and cost-effective fluid analysis using microfluidics.

Main Methods:

Utilized 3D capillary fill microfluidics integrated with monolithically integrated lasers and photodetectors.
Developed a technique to measure local particle velocity by analyzing time-resolved forward scattered light signals.

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Last Updated: Feb 20, 2026

Fluorescence detection methods for microfluidic droplet platforms

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

Leveraged industry-standard compound semiconductor fabrication for scalability.

Main Results:

Successfully demonstrated chip-scale photonic fluid measurements.
Eliminated the need for external fluid speed regulation.
Achieved particle size discrimination (10 and 15 μm polystyrene microbeads) by deriving particle position from scattered light signals.

Conclusions:

The developed system is scalable and manufacturable using existing semiconductor fabrication processes.
This approach offers a feasible solution for integrated, high-precision fluid analysis.
Represents a significant advancement in miniaturized photonic sensing for microfluidic applications.