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Serum SAA1 and APOE are novel indicators for human cytomegalovirus infection
Ni Xie1, Zhonghang Li2, Ran Zuo3
1Institute of Translation Medicine, Shenzhen Second People's Hospital, Sungang West Road, Shenzhen, 518000, China.
Scientific Reports
|October 19, 2017
Abstract:
Human cytomegalovirus (HCMV) infection is a global concern and highly infectious. HCMV-infected individuals are often carriers with damaged immunity. However few diagnostic indicators block HMCV control and prevention. Thus, we measured 21 serum proteins related to HCMV infection using iTRAQ-labeling based quantitative proteomic approaches and SAA1 and APOE were confirmed as candidate serum indicators for identification of HMCV infection according to ROC curve analysis and that co-occurrence of SAA1 and APOE are better markers than individual proteins.