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Related Experiment Videos

Handheld Photoacoustic Microscopy Probe.

Kyungjin Park1, Jin Young Kim2, Changho Lee2,3

  • 1School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Republic of Korea.

Scientific Reports
|October 19, 2017
PubMed
Summary

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This summary is machine-generated.

A new handheld probe using microelectromechanical systems (MEMS) technology enhances optical resolution photoacoustic microscopy (OR-PAM) for faster, in vivo imaging. This compact device enables broader preclinical and clinical applications, including melanoma diagnosis.

Area of Science:

  • Biomedical Optics
  • Microscopy
  • Medical Imaging Technology

Background:

  • Optical resolution photoacoustic microscopy (OR-PAM) offers non-invasive, label-free in vivo imaging with microscopic resolution and high optical contrast.
  • Current OR-PAM systems are limited by large size, fixed configurations, and slow imaging speeds, restricting their clinical and preclinical use.
  • OR-PAM has applications in vessel imaging, flow cytometry, physiological analysis, and single-cell characterization.

Purpose of the Study:

  • To develop a compact, handheld OR-PAM probe using microelectromechanical systems (MEMS) technology.
  • To overcome the limitations of conventional OR-PAM systems, enabling faster imaging and broader applications.
  • To investigate the potential of the handheld probe for clinical diagnosis, such as melanoma detection.

Related Experiment Videos

Main Methods:

  • Development of a handheld OR-PAM probe integrating acoustical, optical, and mechanical components.
  • Utilization of a 2-axis waterproof MEMS scanner (2A-WP-MEMS scanner) for fast scanning capabilities.
  • Integration of all components into a probe with a diameter of 17 mm and a weight of 162 g.

Main Results:

  • The developed handheld probe achieved a high signal-to-noise ratio and image rate.
  • Successful acquisition of phantom and in vivo images, including carbon fibers, microfibers, and mouse ear, iris, and brain.
  • Demonstrated imaging of human mole boundaries and morphology, indicating potential for melanoma diagnosis.

Conclusions:

  • A miniaturized, handheld OR-PAM probe was successfully developed using MEMS technology.
  • The probe offers high performance and portability, expanding the applicability of OR-PAM in research and clinical settings.
  • The handheld OR-PAM probe shows promise for in vivo imaging and non-invasive diagnostic applications, including melanoma detection.