Related Experiment Videos
Effect of cortical kindling on [3H]D-aspartate uptake and glutamate metabolism in rats
M J Leach1, R A O'Donnell, K J Collins
1Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, U.K.
Epilepsy Research
|March 1, 1987
Abstract:
The effects of cortical kindling in rats on [3H]D-aspartate uptake and on glutaminase and glutamine synthetase activities has been studied. The high affinity uptake of [3H]D-aspartate in control cortical tissue (Km approximately 2 microM) was undetectable in the kindled tissue, whilst the enzyme activities were unchanged. A loss of the high-affinity uptake sites for excitatory amino acids may be a contributing factor to the kindling phenomenon.