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Pathologic Correlation of Paramagnetic White Matter Lesions in Adult-Onset Leukoencephalopathy With Axonal Spheroids
Minkyeong Kim1, Hansol Lee1, Hyung Joon Cho1
1Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, South Korea; School of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology, Ulsan, South Korea; Department of Neurology, Pusan National University Hospital, Busan, South Korea; Department of Forensic Medicine; Department of Anatomy; and Medical Research Institute, Pusan National University School of Medicine, Yangsan, South Korea.
Abstract:
It has been proposed that susceptibility-weighted imaging is a sensitive magnetic resonance imaging (MRI) technique for identifying white matter (WM) pathologic changes involving demyelination and iron accumulation. We identified the tree silhouette-like configuration with a paramagnetic phase shift in the frontal subcortical WM lesions of 4 patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia who underwent 3T MRI. According to our postmortem 7T MRI and histologic correlation study to investigate the origin of the susceptibility-related phase contrast, changes in the subcortical WM architecture and central WM loss with the relative preservation of iron-rich U-fibers may contribute to the paramagnetic susceptibility.
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