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Laparoscopic Pancreatoduodenectomy With Modified Blumgart Pancreaticojejunostomy
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Pancreaticojejunostomy: Does the technique matter? A randomized trial.

Anand N Singh1, Sujoy Pal1, Vivek Mangla1

  • 1Department of Gastrointestinal Surgery and Liver Transplantation, All India Institute of Medical Sciences, New Delhi, India.

Journal of Surgical Oncology
|October 19, 2017
PubMed
Summary

The duct-to-mucosa technique for pancreaticojejunostomy (PJ) after pancreaticoduodenectomy (PD) shows no significant difference in preventing postoperative pancreatic fistula (POPF) compared to the dunking technique.

Keywords:
duct-to-mucosadunkinginvaginationpancreaticoduodenectomypancreaticoentericpancreaticojejunostomypancreatoduodenectomywhipple

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Area of Science:

  • Surgical Oncology
  • Gastroenterology
  • Clinical Trials

Background:

  • The optimal method for pancreaticojejunostomy (PJ) following pancreaticoduodenectomy (PD) remains a subject of debate in surgical literature.
  • Two prevalent PJ techniques, duct-to-mucosa and dunking, are commonly employed after PD for periampullary tumors.

Purpose of the Study:

  • To compare the efficacy of the duct-to-mucosa versus the dunking technique of PJ in reducing the incidence of postoperative pancreatic fistula (POPF).

Main Methods:

  • An open-label randomized trial conducted at a tertiary care center between January 2009 and October 2015.
  • 193 patients undergoing PD for resectable periampullary tumors with a pancreatic duct diameter ≥2 mm were randomized to either duct-to-mucosa or dunking PJ.
  • The primary endpoint was the rate of POPF, with secondary analysis of other postoperative complications.

Main Results:

  • The overall POPF rate was 23.8% across both groups.
  • No statistically significant difference in POPF incidence was observed between the duct-to-mucosa (24.7%) and dunking (22.9%) groups (P=0.71).
  • Rates of clinically significant POPF (grades B and C) were also comparable (16.5% vs. 13.5%, P=0.57), as were other postoperative complications.

Conclusions:

  • The duct-to-mucosa PJ technique is not superior to the dunking technique in mitigating the risk of POPF after pancreaticoduodenectomy.
  • Both techniques demonstrate similar safety and efficacy profiles regarding POPF and overall complications.