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Related Concept Videos

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Test Conditions in Macular Visual Field Testing in Glaucoma.

Mariko Eura1, Chota Matsumoto, Shigeki Hashimoto

  • 1Department of Ophthalmology, Kindai University Faculty of Medicine, Ohonohigashi, Osakasayama City, Osaka, Japan.

Journal of Glaucoma
|October 19, 2017
PubMed
Summary
This summary is machine-generated.

Visual field (VF) tests targeting the macula showed the strongest correlation with ganglion cell layer (GCL) thickness between 5-7 degrees eccentricity. Standard Automated Perimetry (SAP) with size I targets and specific perimetry tests, like Matrix, are more suitable for macular testing.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Glaucoma diagnosis and monitoring often rely on visual field (VF) testing to detect peripheral vision loss.
  • The macula, responsible for central and detailed vision, is crucial for daily activities.
  • Assessing macular function in glaucoma requires appropriate visual field test parameters.

Purpose of the Study:

  • To determine optimal visual field (VF) test conditions, including target size, test type, and eccentricity, for evaluating the macular region.
  • To investigate the correlation between ganglion cell layer (GCL) and GCL+IPL thickness and results from six different VF tests.

Main Methods:

  • Thirty-two eyes of glaucoma patients (preperimetric, early, and moderate stages) were tested.
  • Six VF tests were performed: 3 Standard Automated Perimetry (SAP) tests (10-2 HFA SITA size III, 10-2 HFA FULL size III, 10-2 HFA FULL size I) and 3 visual function-specific tests (10-2 SWAP, 10-2 flicker, 10-2 Humphrey Matrix).
  • Ganglion cell layer (GCL) and inner plexiform layer (GCL+IPL) thickness was measured using Spectral Domain Optical Coherence Tomography (SD-OCT). Correlations between visual sensitivity and GCL+IPL thickness were analyzed at different eccentricities (0-5, 5-7, 7-10 degrees).

Main Results:

  • All tested VF methods demonstrated the strongest correlation with GCL+IPL thickness at an eccentricity of 5 to 7 degrees.
  • The Humphrey Matrix test and SAP with size I target showed particularly strong correlations (r=0.52, R=0.52 for Matrix; r=0.44, R=0.46 for SAP size I).
  • Standard Automated Perimetry (SAP) with size III targets showed moderate correlations (r=0.40-0.43, R=0.50-0.53).

Conclusions:

  • Standard Automated Perimetry (SAP) with size I targets and visual function-specific perimetry tests, particularly the Humphrey Matrix, are more suitable for assessing the macular region in glaucoma patients compared to SAP with size III targets.
  • These findings suggest that optimizing VF test parameters can improve the detection of macular dysfunction in glaucoma.