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Relationship Between Optic Nerve Head Drusen Volume and Structural and Functional Optic Nerve Damage.

Alon Skaat^1,2, Stephanie Muylaert¹, Rachel S Mogil^3,4

¹Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai.

Journal of Glaucoma

|October 19, 2017

Summary

Optic nerve head drusen (ONHD) volume correlates with retinal nerve fiber layer (RNFL) thickness and visual field (VF) loss. Larger ONHD volumes are associated with greater structural and functional optic nerve damage.

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Area of Science:

Ophthalmology
Neuro-ophthalmology

Background:

Optic nerve head drusen (ONHD) are calcium-like deposits within the optic nerve head.
The relationship between ONHD volume and associated visual impairment is not fully understood.

Purpose of the Study:

To investigate the association between ONHD volume and retinal nerve fiber layer (RNFL) thickness.
To assess the correlation between ONHD volume and visual field (VF) loss.

Main Methods:

Patients with ONHD underwent serial enhanced depth imaging (EDI) optical coherence tomography (OCT) scans.
Three-dimensional reconstruction software was used to calculate ONHD volume.
RNFL thickness and VF parameters were analyzed in relation to ONHD volume.

Main Results:

ONHD volume significantly correlated with both RNFL thickness and VF mean deviation (P<0.001).
RNFL defects were more prevalent (81%) than VF defects (60%) in eyes with ONHD.
ONHD were most common in the nasal quadrant.

Conclusions:

ONHD volume is a significant predictor of structural and functional damage to the optic nerve.
Early detection and monitoring of ONHD volume may help in managing potential vision loss.