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Inflammatory response and oxidative stress during liver resection
Christoph Schwarz1,2, Fabian Fitschek1, David Bar-Or3,4,5,6
1Department of Surgery and Center for Perioperative Medicine, Medical University of Vienna, Vienna, Austria.
Plos One
|October 19, 2017
Summary
Postoperative complications after liver resection are linked to reduced antioxidant capacity and increased oxidative stress. Monitoring these markers can help predict and manage severe patient outcomes.
Area of Science:
- Hepatobiliary Surgery
- Surgical Complications
- Oxidative Stress Markers
Background:
- Postoperative complications remain a significant challenge following liver resection (LR).
- Systemic inflammation and oxidative stress (OS) during major abdominal surgery can negatively impact outcomes after hepatectomy.
Purpose of the Study:
- To investigate the perioperative changes in oxidative stress and antioxidant capacity markers following liver resection.
- To determine the correlation between these markers and the development of severe postoperative complications.
Main Methods:
- Forty patients undergoing liver resection were enrolled.
- Static oxidation-reduction potential markers (sORP) and antioxidant capacity ORP (cORP) were measured using the RedoxSYS system.
- Th1 and Th2 cytokines were assessed perioperatively.
Main Results:
- Antioxidant capacity (cORP) significantly decreased post-surgery, while sORP remained stable.
- A strong correlation was observed between sORP and cORP (R²:0.457).
- An increase in OS (sORP) >3 mV predicted severe postoperative complications (53.8% vs. 12.5%; p=0.017), alongside elevated IL-2 and IL-5 levels.
Conclusions:
- Antioxidant capacity declines post-liver resection, indicating consumption to manage oxidative stress.
- A pronounced inflammatory response during surgery, indicated by elevated cytokines, is associated with severe postoperative complications.
