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Related Experiment Video

Updated: Feb 20, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence.

Esperanza Fernández¹, Mark O Collins², René A W Frank³

¹Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK; KU Leuven, Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), and VIB Center for the Biology of Disease, Leuven, Belgium.

|October 19, 2017

Summary

This summary is machine-generated.

Researchers identified how the neuronal protein Arc and PSD95 form large complexes. These Arc-PSD95 complexes are linked to cognitive disorders like schizophrenia and intellectual disability.

Keywords:

Arc PSD95 cognition genetic variants intellectual disability schizophrenia supercomplexes synaptic complexes tandem affinity purification

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Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Published on: September 3, 2014

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

The activity-regulated neuronal protein Arc's interactions and complex assembly are poorly understood.
Its role in human cognition and disease remains largely unknown.

Purpose of the Study:

To investigate the native interactions and complexes of the Arc protein.
To determine the role of Arc-PSD95 complexes in human cognitive function and neurological disorders.

Main Methods:

Utilized a proteomic and genetic strategy in mice, tagging the endogenous Arc gene.
Performed biochemical and proteomic characterization of native Arc complexes in wild-type and knockout mice.
Integrated human genetic data with proteomic findings.

Main Results:

Identified numerous Arc-interacting proteins, with PSD95 being the most abundant.
PSD95 is crucial for Arc assembly into large (1.5-MDa) complexes and synaptic recruitment.
Arc-PSD95 complexes are associated with mutations and variants in schizophrenia, intellectual disability, autism, epilepsy, and intelligence.

Conclusions:

Arc forms significant multiprotein complexes with PSD95 at excitatory synapses.
These Arc-PSD95 complexes are implicated in the molecular mechanisms underlying cognitive function and neurological diseases.