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[Association between serum 25(OH)D levels at birth and bronchopulmonary dysplasia in preterm infants]

Ren-Qiang Yu1, Dao-Zhen Chen, Qin Zhou

  • 1Department of Neonatology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, China. ys0129007@sina.cn.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|October 20, 2017
PubMed

Insights

Vitamin D deficiency at birth is linked to bronchopulmonary dysplasia (BPD) in preterm infants. Lower serum 25-hydroxyvitamin D [25(OH)D] levels at birth correlated with higher BPD incidence.

Area of Science:

  • Neonatal Medicine
  • Nutritional Science
  • Pediatric Respiratory Medicine

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant complication in preterm infants.
  • Vitamin D plays a crucial role in immune function and lung development.
  • Low vitamin D levels are common in preterm infants.

Purpose of the Study:

  • To investigate the association between cord blood serum 25-hydroxyvitamin D [25(OH)D] levels and the development of BPD.
  • To determine if vitamin D deficiency at birth is a risk factor for BPD in premature neonates.

Main Methods:

  • A cohort of preterm infants (gestational age < 34 weeks) born between 2014-2016 was studied.
  • Infants were categorized into BPD and control groups.
  • Serum 25(OH)D levels at birth were measured and compared between groups.

Main Results:

  • Infants who developed BPD had significantly lower serum 25(OH)D levels at birth compared to controls (37±17 vs 47±20 nmol/L, P<0.05).
  • The prevalence of vitamin D deficiency (<25 nmol/L) was substantially higher in the BPD group (90.2% vs 74.0%, P<0.05).
  • Serum 25(OH)D levels showed a significant negative correlation with BPD incidence (r=-0.201, P=0.001).

Conclusions:

  • Vitamin D deficiency at birth may be associated with an increased risk of developing BPD in preterm infants.
  • Further investigation using multivariate analysis is warranted to confirm this association and elucidate the underlying mechanisms.
Abstract

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