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Updated: Feb 20, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

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Interpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer Immunotherapy

Dinler A Antunes1,2, Maurício M Rigo1,3, Martiela V Freitas1

  • 1Núcleo de Bioinformática do Laboratório de Imunogenética (NBLI), Department of Genetics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Frontiers in Immunology
|October 20, 2017
PubMed
Summary

T-cell cross-reactivity is a safety concern in cancer immunotherapy. Structural analysis of peptide-MHC complexes can predict and potentially mitigate these unwanted immune responses, improving therapy safety.

Keywords:
T-cell cross-reactivityTCR-interacting surfaceTCR/pMHCcancer immunotherapycross-reactivity hot-spotshierarchical clusteringpeptide–MHC complex

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