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Published on: July 11, 2025
Rejection sensitivity as a vulnerability marker for depressive symptom deterioration in men
Jannika De Rubeis1, Ricardo G Lugo2, Michael Witthöft3
1Institute for Health and Behaviour, Research Unit INSIDE, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Rejection sensitivity (RS) predicts depression relapse in men. Targeting RS during treatment and follow-up care is crucial for preventing symptom deterioration in male patients with depressive disorders.
Area of Science:
- Psychiatry
- Clinical Psychology
- Mental Health Research
Background:
- Men are underrepresented in mood disorders and less likely to seek psychological help.
- Higher suicide rates in males suggest potential underreporting of depression.
- Rejection Sensitivity (RS) is a disposition to anxiously perceive and respond to rejection cues.
Purpose of the Study:
- To investigate the longitudinal predictive role of Rejection Sensitivity (RS) on symptom deterioration.
- To examine RS's impact on depression relapse 6 months post-treatment in male inpatients.
- To assess if RS predicts worsening depressive symptoms after treatment completion.
Main Methods:
- A study involving 72 male inpatients diagnosed with depressive spectrum disorder.
- Beck Depression Inventory (BDI) administered at intake, end-of-treatment, and 6-month follow-up.
- Rejection Sensitivity (RS) scores were collected at the study's intake.
Main Results:
- Rejection Sensitivity (RS) demonstrated additional predictive power for BDI scores at 6-month follow-up.
- RS predicted symptom deterioration even after controlling for end-of-treatment BDI scores (ΔR2 = .095).
- This finding highlights RS as a significant factor in depression relapse for men.
Conclusions:
- Targeting Rejection Sensitivity (RS) during therapy is important for male depression treatment.
- Therapeutic follow-up care is paramount in preventing relapse in male patients.
- Future research should explore mediators like self-blame and rumination in the RS-relapse link.
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