Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.5K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.5K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.4K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.4K
Arteries and Arterioles01:16

Arteries and Arterioles

7.0K
Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles...
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Strategies and innovative practices of European minimally invasive surgery for gastroesophageal reflux disease].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2026
Same author

[Preliminary application of patient-derived tumor organoids in biliary tract cancers: analysis of 38 cases].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2025
Same author

[Visualizing the evidence of robotic gastrointestinal surgery based on guideline recommendations: an evidence mapping study of gastric and colorectal cancer].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2025
Same author

[Transscleral ciliary surgery in glaucoma:from destructive surgery to minimally invasive surgery].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2024
Same author

[Establishment of a prognostic model for non-nephrotic membranous nephropathy based on unbalanced data].

Zhonghua yi xue za zhi·2023
Same author

[Constructing the Bayesian network models to explore the factors related to glomerular and tubular injury].

Zhonghua yi xue za zhi·2023
Same journal

[The era of precision diagnosis and treatment for optic neuritis: advances in diagnostic classification, biomarkers and therapeutic strategies].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
Same journal

[Application value of ocular multimodal imaging methods in the evaluation of increased intracranial pressure].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
Same journal

[Secondary panuveitis after ocular wasp sting: a case report].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
Same journal

[Correlation of ocular surface changes with filtering bleb morphology after antiglaucoma surgery for primary angle-closure glaucoma].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
Same journal

[Regulation of SARM1 on SNPH expression and its participation in glaucomatous optic neuropathy].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
Same journal

[Construction of a regulated <i>Crat</i> overexpression system in mouse hippocampal neuronal HT22 cell line].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
See all related articles

Related Experiment Video

Updated: Feb 20, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.7K

[The vessel and primary glaucoma].

R S Li1, Y Z Pan

  • 1Department of Ophthalmology of Peking University First Hospital, Beijing 100034, China.

[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|October 20, 2017
PubMed
Summary
This summary is machine-generated.

Glaucoma, a leading cause of irreversible blindness, involves optic nerve damage. Research explores vascular factors and uses Angio-OCT to visualize ocular perfusion, offering new insights into glaucoma

Keywords:
GlaucomaMicrocirculationOptic diskRetinal vessels

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.9K
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.9K

Related Experiment Videos

Last Updated: Feb 20, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.7K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.9K
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.9K

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Vascular Biology

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide, characterized by chronic progressive optic neuropathy.
  • The precise pathogenesis of glaucoma remains incompletely understood.
  • The vascular hypothesis suggests a link between vascular status and glaucoma development, but direct evidence is limited.

Purpose of the Study:

  • To review and summarize existing literature on vascular factors associated with glaucoma.
  • To highlight the role of emerging technologies like Angio-OCT in understanding glaucoma pathogenesis.
  • To provide references for future clinical research on glaucoma vascular mechanisms.

Main Methods:

  • Comprehensive literature review of studies investigating vascular diameter, tortuosity, location, perfusion, regulation, and systemic factors in glaucoma.
  • Analysis of research utilizing Optical Coherence Tomography (OCT), particularly Angio-OCT, for in vivo ocular perfusion assessment.
  • Synthesis of evidence linking vascular dysfunction in the optic nerve head to glaucoma.

Main Results:

  • Numerous studies have explored various vascular parameters in relation to glaucoma.
  • Angio-OCT provides unprecedented real-time visualization and measurement of ocular perfusion.
  • New evidence suggests vascular dysfunction of the optic nerve head is associated with glaucoma.

Conclusions:

  • Vascular factors are increasingly implicated in the pathogenesis of glaucoma.
  • Advanced imaging techniques like Angio-OCT are crucial for elucidating the role of ocular hemodynamics in glaucoma.
  • Further research is needed to establish definitive causal links and therapeutic targets related to vascular dysfunction in glaucoma.