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Updated: Feb 20, 2026
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Draft genome sequences of three multidrug-resistant Cutibacterium (formerly Propionibacterium) acnes strains isolated
Nanxue Zhang1, Zhong Lu1, Ying Ma1
1Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Objectives:
Cutibacterium acnes (formerly Propionibacterium acnes), an anaerobic Gram-positive bacterium, is a skin commensal and is considered to be associated with acne. Here we report the draft genome sequences of three multidrug-resistant (MDR) C. acnes strains (CA17, CA39 and CA51) isolated from skin lesions of acne patients in China.
Methods:
The whole genomes of the three MDR C. acnes strains were sequenced using an Illumina HiSeq 2500 platform. De novo assembly and annotation were performed with SPAdes 3.5.0 and NCBI Prokaryotic Genome Annotation Pipeline (PGAP), respectively.
Results:
The genomes of the three strains are as follows: 2 488 255bp containing 2494 genes and 2266 coding sequences (CDSs) for CA17; 2 484 088bp containing 2515 genes and 2376 CDSs for CA39; and 2 483 437bp containing 2515 genes and 2372 CDSs for CA51. Each strain has 45 tRNAs and 3 rRNAs.
Conclusions:
The genome sequences of the three MDR C. acnes strains may provide foundations for further research into the resistance mechanisms of antibiotic-resistant C. acnes strains and their role in disease pathogenesis.
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