Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.9K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.9K
The Parathyroid Glands00:59

The Parathyroid Glands

5.4K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
5.4K
Bone Disorders01:29

Bone Disorders

5.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.6K
Bone Remodeling01:40

Bone Remodeling

40.6K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.6K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

6.2K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
6.2K
What is the Skeletal System?01:02

What is the Skeletal System?

57.9K
Overview
57.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alendronate for 6 or 12 months following denosumab discontinuation in women with postmenopausal osteoporosis: A prospective observational study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Osteoporosis and osteoporosis therapies as determinants of implant fixation failure in arthroplasty and spinal fusion constructs: a position statement from the Fracture Working Group of the Council of Scientific Advisors of the International Osteoporosis Foundation.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

Magnesium as an endocrine modulator: physiological roles, clinical evidence, and therapeutic perspectives.

European journal of endocrinology·2026
Same author

Exploring the relationship between microplastic exposure and bone health.

Endocrine connections·2026
Same author

Artificial intelligence vs human opportunistic detection of vertebral fractures in routine CT scans: results of a pilot study.

Hormones (Athens, Greece)·2026
Same author

Romosozumab for the treatment of thalassemia-associated osteoporosis in two female patients.

JBMR plus·2026

Related Experiment Video

Updated: Feb 20, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.4K

Bone disease in primary hyperparathyroidism.

Polyzois Makras1, Athanasios D Anastasilakis2

  • 1Department of Endocrinology and Diabetes, 251 Hellenic Air Force & VA General Hospital, Athens, Greece.

Metabolism: Clinical and Experimental
|October 21, 2017
PubMed
Summary

Primary hyperparathyroidism (PHPT) causes high bone turnover and fracture risk. Early diagnosis and treatments like parathyroidectomy or bisphosphonates improve bone health.

Keywords:
BisphosphonateBone mineral densityFractureHyperparathyroidismParathyroid hormone

More Related Videos

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

15.4K
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

5.0K

Related Experiment Videos

Last Updated: Feb 20, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.4K
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

15.4K
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

5.0K

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Skeletal Health

Background:

  • Primary hyperparathyroidism (PHPT) is characterized by high bone turnover, reduced bone mineral density (BMD), and increased fracture risk.
  • Modern imaging techniques reveal microarchitectural bone disturbances contributing to fragility.

Purpose of the Study:

  • To review the skeletal manifestations of PHPT.
  • To discuss current and potential therapeutic strategies for bone health in PHPT patients.

Main Methods:

  • Literature review of studies on PHPT, bone density, microarchitecture, and treatment efficacy.
  • Analysis of imaging modalities (high-resolution peripheral quantitative computed tomography, trabecular bone score) and therapeutic agents (parathyroidectomy, bisphosphonates, cinacalcet).

Main Results:

  • Parathyroidectomy demonstrates long-term skeletal benefits, recommended for suspected bone fragility.
  • Bisphosphonates improve BMD; cinacalcet shows no effect on bone strength.
  • Combined bisphosphonates and cinacalcet is theoretically sound but lacks robust study data.

Conclusions:

  • Parathyroidectomy is a key treatment for PHPT with bone fragility.
  • Bisphosphonates are effective for BMD improvement; combination therapy needs further investigation.
  • Adequate calcium and vitamin D intake are crucial, with careful monitoring.