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Anatomical and functional correlation in Susac syndrome: multimodal imaging assessment
Alexandre G B Azevedo1, Luiz H Lima1, Léo Müller1
1Departamento de Oftalmologia - Secretaria Administrativa, Universidade Federal de São Paulo, Rua Botucatu, 821, 1o Andar, São Paulo, 04023-062 Brazil.
International Journal of Retina and Vitreous
|October 21, 2017
Summary
Optical coherence tomography angiography (OCTA) reveals retinal vascular non-perfusion in Susac's syndrome (SuS). OCTA findings correlate with visual field and microperimetry test results, aiding diagnosis and monitoring of this rare condition.
Area of Science:
- Ophthalmology
- Neuro-ophthalmology
- Medical Imaging
Background:
- Susac's syndrome (SuS) is a rare condition causing retinal microangiopathy.
- Optical coherence tomography angiography (OCTA) offers detailed retinal microvasculature mapping.
- This report details multimodal imaging in SuS, correlating OCTA with functional tests.
Observation:
- A case of Susac's syndrome in a 31-year-old patient was reviewed.
- Multimodal imaging included color fundus photography, FA, OCTA, microperimetry, and visual field testing.
- OCTA revealed superficial and deep retinal vascular hypoperfusion in both eyes.
Findings:
- Fluorescein angiography showed branch retinal arterial occlusion and peripheral vascular leakage.
- OCTA demonstrated retinal vascular non-perfusion but normal choriocapillaris.
- Reduced visual field and microperimetry sensitivity precisely mapped to OCTA-identified hypoperfusion areas.
Implications:
- OCTA effectively visualizes retinal vascular changes in Susac's syndrome.
- OCTA findings correlate with functional deficits, aiding in diagnosis and management.
- This imaging modality enhances understanding of SuS pathophysiology and patient outcomes.
