Peptide-based fibrin-targeting probes for thrombus imaging.

Area of Science:

• Biomedical imaging
• Molecular imaging
• Cardiovascular research

Background:

• Thrombosis imaging is a critical unmet need.
• Molecular imaging offers non-invasive detection of thrombus.
• Fibrin is a key target due to its abundance and role in thrombus formation.

Purpose of the Study:

• To review fibrin-targeted probes for thrombosis imaging.
• To highlight advancements in MRI, PET, SPECT, and optical techniques.
• To emphasize the progression of a specific PET probe ([64Cu]FBP8) into clinical trials.

Main Methods:

• Overview of recent fibrin-targeted molecular imaging probes.
• Focus on techniques including MRI, PET, SPECT, and optical imaging.
• Detailed examination of research conducted over 15 years, including the development of [64Cu]FBP8.

Main Results:

• Fibrin-targeted probes can detect thrombus in various models and patients.
• The fibrin-binding PET probe [64Cu]FBP8 has advanced from preclinical to human studies.
• Multiple imaging modalities show potential for thrombosis visualization.

Conclusions:

• Fibrin-targeted molecular imaging is a viable strategy for thrombosis detection.
• The [64Cu]FBP8 PET probe represents a significant advancement in clinical translation.
• Continued development of these probes is essential for managing thrombotic diseases.