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Updated: Feb 20, 2026

HUVEC Tube-formation Assay to Evaluate the Impact of Natural Products on Angiogenesis
Published on: June 24, 2019
Antiangiogenic phenylpropanoid glycosides from Gynura cusimbua
Qinge Ma1,2, Rongrui Wei2,3, Bin Zhou1
1a College of Pharmacy , Jiangxi Science & Technology Normal University , Nanchang , China.
Abstract:
A new phenylpropanoid glycoside, named α-L-rhamnopyranosyl-(1↔2)-β-D-[4″-(8E)-7-(3,4-dihydroxyphenyl)-8-propenoate, 1″-O-(7S)-7-(3,4-dihydroxyphenyl)-7-methoxy-ethyl]-glucopyranoside (1), together with nine known compounds (2-10) were isolated from the active fraction (n-Butanol fraction) of Gynura cusimbua for the first time. The known compounds (2-10) were identified as phenylpropanoid glycosides on the basis of extensive spectral data and references. The antiangiogenic activities of compounds (1-10) were evaluated by MTT assay on HUVECs and wild-type zebrafish in vivo model assay. As a result, compounds 1, 6, 7, 8 and 10 exhibited certain antiangiogenic activities.
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