[Changes in sensitivity of lymphocyte cholinergic receptors in patients with breast cancer]

Alteration of the cholinoreceptor sensitivity of peripheral blood lymphocytes in patients with breast cancer was studied by the lymphocyte adhesion inhibition test (LAI-test). It has been shown that acetylcholine stimulates the LAI-reaction in optimal concentrations of 10(-7)-10(-8) M. Specific antagonists (m-cholinoblocker of atropin and n-cholinoblocker of hexonium) being used, it is demonstrated that the revealed cholinergic enhancement of the lymphocyte adherence inhibition is mediated through the stimulating influence of acetylcholine on m-cholinoreceptors. It is established that the lymphocyte cholinoreceptor sensitivity of the patients with breast cancer at the advanced stages is significantly lower than in patients with breast cancer at early stages.