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Sudden death: Neurogenic causes, prediction and prevention
Nina Japundžić-Žigon1, Olivera Šarenac1, Maja Lozić1
11 Faculty of Medicine, University of Belgrade, Serbia.
European Journal of Preventive Cardiology
|October 21, 2017
Summary
Sudden death, often cardiac, stems from autonomic nervous system imbalance. This review explores causes, diagnosis via autonomic markers, and prevention through electrical neuromodulation.
Area of Science:
- Cardiology
- Neurology
- Autonomic Neuroscience
Background:
- Sudden death is a significant global health concern.
- While cardiac causes are most common, neurological conditions and other factors also contribute.
- A unifying feature is autonomic nervous system (ANS) imbalance affecting cardiovascular control.
Purpose of the Study:
- To review pathologies underlying sudden death.
- To emphasize the role of the ANS in sudden death.
- To discuss diagnostic, prognostic, and preventive strategies.
Main Methods:
- Literature review of sudden death pathologies.
- Focus on ANS contribution and cardiovascular control.
- Analysis of clinical and autonomic markers for diagnosis and prognosis.
Main Results:
- Diverse pathologies share ANS imbalance as a commonality.
- Autonomic markers like heart rate variability and baroreflex sensitivity aid diagnosis and prognosis.
- Electrical neuromodulation presents a promising prevention strategy.
Conclusions:
- Understanding ANS dysfunction is crucial for addressing sudden death.
- Early diagnosis and prognosis can be improved using autonomic markers.
- Electrical neuromodulation offers a novel approach for preventing sudden death.
