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Vedroprevir in the management of hepatitis C virus infection

Ameer Abutaleb1, Shyamasundaran Kottilil1

  • 1a Division of Clinical Care and Research, Institute of Human Virology , University of Maryland School of Medicine , Baltimore , MD , USA.

Expert Opinion on Investigational Drugs
|October 21, 2017
PubMed

Insights

New direct-acting antivirals (DAAs) offer improved Hepatitis C Virus (HCV) treatment. Vedroprevir (GS-9451) effectively shortens treatment duration when combined with other DAAs, achieving high cure rates.

Area of Science:

  • Hepatology and Viral Hepatitis Research
  • Pharmacology of Antiviral Agents

Background:

  • Hepatitis C Virus (HCV) infection is a primary cause of liver failure and transplantation globally.
  • Direct-acting antivirals (DAAs) have revolutionized HCV therapy, offering shorter durations and higher efficacy compared to older treatments.

Purpose of the Study:

  • To review the literature on the use of Vedroprevir (GS-9451) for Hepatitis C Virus treatment.
  • To evaluate Vedroprevir's efficacy in diverse patient populations and its role in combination therapy.

Main Methods:

  • Literature review of articles on Vedroprevir (GS-9451) accessible via MEDLINE/PubMed.
  • Analysis of chemistry, pharmacology, and clinical efficacy data for Vedroprevir in HCV treatment.

Main Results:

  • Vedroprevir (GS-9451) demonstrates high effectiveness in reducing treatment duration when used with other DAAs.
  • Monotherapy with GS-9451 is not recommended due to rapid development of resistance.
  • Combination therapy is essential for achieving sustained virologic response (SVR).

Conclusions:

  • Vedroprevir is a valuable component in combination DAA regimens for HCV.
  • Combining Vedroprevir with other DAAs enhances treatment success without compromising outcomes.
  • Effective HCV eradication requires combination therapy due to resistance potential of GS-9451.
Abstract

Keywords:
GS-9451Hepatitis C virusdirect-acting antiviralsvedroprevir

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