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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

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Related Experiment Video

Updated: Feb 20, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

MicroRNAs expression profile in solid and unicystic ameloblastomas.

A Setién-Olarra¹, X Marichalar-Mendia¹, N G Bediaga²

¹Oral Medicine and Pathology, Department of Stomatology II, University of the Basque Country (UPV/EHU), Leioa, Spain.

|October 21, 2017

Summary

Researchers identified microRNA signatures in ameloblastomas, revealing differences between solid/multicystic (SA) and unicystic (UA) types. MiR-489 may help distinguish between these odontogenic tumors.

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Area of Science:

Oral pathology
Molecular biology
Oncology

Background:

Odontogenic tumors (OTs) include ameloblastomas, which can be locally aggressive with high recurrence rates.
Solid/multicystic ameloblastoma (SA) is more aggressive than unicystic ameloblastoma (UA).
MicroRNA deregulation is linked to neoplastic development.

Purpose of the Study:

To determine microRNA expression profiles in SA and UA.
To identify potential biomarkers for ameloblastoma behavior and classification.

Main Methods:

MicroRNA expression profiling using TaqMan® Low Density Arrays (TLDAs) on 24 samples (8 SA, 8 UA, 8 controls).
Validation via quantitative RTqPCR on an independent cohort (19 SA, 8 UA, 19 dentigerous cysts).

Main Results:

Identified 40 differentially regulated microRNAs in ameloblastomas, associated with neoplastic development, differentiation, and osteogenesis.
Validated significant expression differences for 6 microRNAs between SA and UA.
Found 7 microRNAs differentially expressed in SA and 6 in UA compared to controls.
Identified miR-489 as differentially expressed in both SA and UA.

Conclusions:

A novel microRNA signature for ameloblastoma and its subtypes (SA and UA) was identified.
This signature may enhance understanding of ameloblastoma etiopathogenesis.
MiR-489 shows potential as a biomarker to differentiate between SA and UA.