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Updated: Feb 20, 2026
06:04
Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
639
Potential of transcatheter aortic valve replacement to improve post-procedure renal function
Bruno L R Faillace1, Henrique B Ribeiro1, Carlos M Campos1
1Heart Institute (InCor) of São Paulo University Medical School (USP), São Paulo, Brazil.
Summary
Transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis often does not worsen kidney function. A notable percentage of patients actually experience acute kidney function improvement after TAVR.
Area of Science:
- Cardiology
- Nephrology
- Interventional Cardiology
Background:
- Patients undergoing transcatheter aortic valve replacement (TAVR) frequently have baseline comorbidities, including renal dysfunction.
- These comorbidities can increase the risk of acute kidney injury (AKI) post-TAVR, though some may improve renal function.
Purpose of the Study:
- To evaluate the potential for TAVR to acutely improve post-procedure renal function.
- To assess renal function changes in patients undergoing TAVR.
Main Methods:
- Prospective single-center registry of consecutive patients with severe symptomatic aortic stenosis treated with transfemoral TAVR.
- Creatinine levels monitored daily until discharge; AKI defined by VARC-2 criteria.
- TAVR-induced renal function improvement (TIRFI) defined as >25% creatinine level improvement.
Main Results:
- 69 patients (mean age 83.0±7.4 years) included; 35.4% developed AKI.
- Patients with severe renal dysfunction or diabetes had higher AKI rates (50% and 56.3%, respectively).
- Acute kidney recovery (TIRFI) occurred in 18.5% of patients; 88.6% left hospital with stable or improved renal function.
Conclusions:
- TAVR did not impair renal function in the majority of selected patients, despite comorbidities and contrast media use.
- A significant proportion of patients demonstrated acute renal function improvement post-TAVR.
- TAVR appears safe regarding renal function in this patient cohort.
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