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Getting to the Core of the Dermal Papilla
Mingxing Lei1, Li Yang2, Cheng-Ming Chuong3
1"111" Project Laboratory of Biomechanics and Tissue Repair and Key Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA; Integrative Stem Cell Center, China Medical University Hospital, China Medical University, Taichung, Taiwan; Institute of New Drug Development, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.
Abstract:
Through coordinated and reciprocal interactions between the epithelium and mesenchyme, diverse integumentary organs form and undergo cyclic renewal. The hair follicle has become the main model to understand this extraordinary regenerative behavior. At the core is the dermal papilla, the organizing center, and the epithelial stem cells that respond to dermal papilla signaling. Two recent papers by Telerman et al. and Yang et al. unravel new molecular landscapes within the dermal papilla.
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