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Genomic Insights into Cardiomyopathies: A Comparative Cross-Species Review

Siobhan Simpson1, Paul Rutland2, Catrin Sian Rutland3

  • 1Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK. Siobhan.simpson@nottingham.ac.uk.

Veterinary Sciences
|October 24, 2017
PubMed

Insights

Cardiovascular disease is a leading cause of death. This review compares cardiomyopathies in humans and animals, identifying genetic links and suggesting improved diagnostics and breeding programs for better cardiac care.

Area of Science:

  • Comparative medicine
  • Genetics
  • Cardiology

Background:

  • Cardiovascular disease is the leading cause of non-communicable death globally.
  • Annual deaths from cardiovascular disease are projected to exceed 20 million by 2030.

Purpose of the Study:

  • To compare cardiomyopathies in human and non-human animal populations.
  • To identify genetic associations for cardiomyopathies across species.
  • To explore interspecies benefits for advancing cardiac medicine.

Main Methods:

  • Literature review comparing human and animal cardiomyopathies.
  • Analysis of genetic associations in various species.
  • Synthesis of findings for translational medical applications.

Main Results:

  • Identified genetic links for cardiomyopathies in both humans and diverse animal models.
  • Highlighted species-specific differences and commonalities in cardiac disease.

Conclusions:

  • Animal models offer valuable insights for human cardiac disease research.
  • Human genomic data can advance veterinary cardiology.
  • Recommendations include enhanced screening, genetic testing, and breeding programs for non-human animals.

Keywords:
caninecardiomyopathycardiovascular diseasecross-speciesgeneticshuman

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