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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Biomolecule-Responsive Hydrogels in Medicine.

Ghorbanali Sharifzadeh1, Hossein Hosseinkhani2

  • 1Department of Polymer Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310, Johor, Malaysia.

Advanced Healthcare Materials
|October 24, 2017
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Biomolecule-responsive hydrogels show promise but require further research for clinical use. Key factors like biocompatibility and material properties must be optimized for safe and effective applications.

Keywords:
biomoleculesglucosenucleic acidsproteinssmart hydrogelsstimuli-responsive hydrogels

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Biomolecule-responsive hydrogels, including glucose-, protein-, and nucleic acid-responsive types, have advanced significantly.
  • Their translation to preclinical and clinical settings remains nascent, necessitating innovative design strategies.

Purpose of the Study:

  • To highlight recent advances in biomolecule-responsive hydrogels.
  • To identify challenges and future directions for clinical applications of these hydrogels.

Main Methods:

  • Review of current literature on biomolecule-responsive hydrogels.
  • Analysis of factors critical for in vitro and in vivo evaluation.

Main Results:

  • Recent progress in glucose-, protein-, and nucleic acid-responsive hydrogels is detailed.
  • Critical evaluation parameters for hydrogel application include biocompatibility, biointegration, and toxicity.
  • Material properties such as physical nature, chemical structure, surface characteristics, and degradation significantly influence tissue interactions.

Conclusions:

  • Further research is crucial for the clinical translation of biomolecule-responsive hydrogels.
  • Development of hydrogels with tunable biological and mechanical properties and minimal side effects is essential.
  • Rigorous in vitro and in vivo studies are required to assess biocompatibility, biointegration, and toxicity.