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Updated: Feb 10, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Enantioselective syntheses of atropisomers featuring a five-membered ring
1Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, France. damien.bonne@univ-amu.fr jean.rodriguez@univ-amu.fr.
Abstract:
Atropisomerism is a fundamental property of molecules featuring a hindered rotation around a chemical bond. If six-membered ring biaryl or heterobiaryl atropisomers are the most popular ones, the focus of this feature article will be put on less common and more challenging five-membered ring containing atropisomers displaying either a stereogenic C-N or C-C bond. After an historical background, a description of the latest flourishing enantioselective strategies for the construction of this attractive family of atropisomers will be presented.
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