Related Experiment Video

Updated: Feb 20, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.7K

Cardiac Remodeling Patterns in Severe Obesity According to Arterial Hypertension Grade

Roberto de Cleva1,2, Victor Arrais Araujo3, Carla Cristina Ornelas Buchalla3

  • 1Hospital das Clínicas, Gastroenterology Department, University of São Paulo Medical School, AV. Dr. Arnaldo, 455, Cerqueira César, São Paulo, SP, CEP: 01246-000, Brazil. roberto.cleva@uol.com.br.

Obesity Surgery
|October 24, 2017
PubMed

Insights

Arterial hypertension (AHT) is a stronger predictor of left ventricular hypertrophy (LVH) than obesity grade in severely obese patients. Higher AHT grades significantly increase LVH risk, while BMI is an independent risk factor only above a certain threshold.

Area of Science:

  • Cardiology
  • Obesity Medicine
  • Hypertension Research

Background:

  • Severe obesity is associated with increased cardiovascular risk.
  • Left ventricular hypertrophy (LVH) is a common complication in obese individuals.
  • Arterial hypertension (AHT) is a major risk factor for cardiac remodeling.

Purpose of the Study:

  • To investigate the correlation between left ventricular hypertrophy (LVH) patterns and grades of severe obesity and arterial hypertension (AHT).
  • To determine the independent and additive effects of obesity and AHT on LVH prevalence.

Main Methods:

  • A cross-sectional prospective study involving 379 severely obese patients.
  • Obesity classified by BMI (morbidly obese: 40-50 kg/m², super obese: >50 kg/m²).
  • Arterial hypertension classified into grades 1 and 2; LVH assessed by transthoracic echocardiography.

Main Results:

  • LVH was present in 58.6% of patients.
  • Obesity and AHT demonstrated additive effects on LVH prevalence.
  • AHT was a significant predictor of LVH (OR 1.97), with grade 2 hypertension conferring a 4.31-fold greater risk.
  • BMI > 47.17 kg/m² was an independent risk factor for LVH (OR 1.62).

Conclusions:

  • Arterial hypertension is a more potent predictor of left ventricular hypertrophy than obesity grade in this cohort.
  • Management of hypertension is crucial for preventing LVH in severely obese individuals.
Abstract

Keywords:
HypertensionLeft ventricular hypertrophySevere obesity

More Related Videos

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

6.9K
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.6K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.1K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.1K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
545
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
456
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.1K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.2K