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Updated: Feb 20, 2026

A Method to Study de novo Formation of Chromatin Domains
Published on: August 23, 2019
Broad Chromatin Domains: An Important Facet of Genome Regulation
Francesco N Carelli1, Garima Sharma1, Julie Ahringer1
1The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QN, United Kingdom.
Abstract:
Chromatin composition differs across the genome, with distinct compositions characterizing regions associated with different properties and functions. Whereas many histone modifications show local enrichment over genes or regulatory elements, marking can also span large genomic intervals defining broad chromatin domains. Here we highlight structural and functional features of chromatin domains marked by histone modifications, with a particular emphasis on the potential roles of H3K27 methylation domains in the organization and regulation of genome activity in metazoans.
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