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CD4+ lymphocytes are extracted from blood by peripheral lymph nodes at different rates from other T cell subsets and
E A Washington1, W G Kimpton, R N Cahill
1Department of Veterinary Preclinical Sciences, University of Melbourne, Parkville, Victoria, Australia.
Abstract:
The circulation of lymphocyte subsets through prescapular lymph nodes in sheep has been quantified using a panel of monoclonal antibodies against sheep lymphocyte surface antigens. Differences in the extraction of lymphocyte subsets from blood by the lymph node were found with CD4+ lymphocytes being extracted at a faster rate (1/2) than CD8+, SBU-T19+, major histocompatibility complex class II+ and B cells (1/4 to 1/5). In order to accommodate existing data on organ-specific adhesion molecules, one subset specific and one tissue specific, expressed on vascular endothelium could act jointly to regulate the migration of recirculating lymphocytes.