Angiosome based time series analysis of deep tissue perfusion using diffuse speckle contrast analysis.
Summary
This study introduces a novel optical method, diffuse speckle contrast analysis (DSCA), to measure blood flow in the foot. Preliminary findings suggest that blood flow signals in the posterior tibial artery angiosome lead those in other foot areas.
Area of Science:
- Biomedical optics
- Vascular physiology
- Microcirculation research
Background:
- Angiosomes, defined by arterial supply, are crucial in vascular surgery.
- The precise link between arterial flow and angiosome microcirculation requires further investigation.
- Current methods for assessing angiosome perfusion are limited.
Purpose of the Study:
- To introduce a novel optical approach for simultaneous microcirculation assessment within different angiosomes.
- To investigate the relationship between arterial flow and low-frequency oscillations (LFO) within foot angiosomes.
- To explore the potential of cross-correlation analysis for understanding angiosome dynamics.
Main Methods:
- Development and application of a four-channel diffuse speckle contrast analysis (DSCA) system.
- Simultaneous measurement of blood perfusion in distinct foot regions.
- Analysis of cross-correlation between LFO signals from different DSCA channels.
Main Results:
- The DSCA system successfully measured blood perfusion across multiple foot areas.
- Significant cross-correlation was observed between LFO signals from different angiosomes.
- The LFO signal from the posterior tibial artery angiosome consistently led signals from other channels.
Conclusions:
- The four-channel DSCA is a promising optical tool for evaluating angiosome perfusion.
- Low-frequency oscillations show correlated patterns within a single angiosome.
- The posterior tibial artery plays a leading role in the dynamic perfusion of the foot's angiosomes.
