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Exploring the Spectrum of Subcortical Hyperintensities and Cognitive Decline

Yi-Chun Chen1, Hsien-Hao Tsao1, Yi-Chuan Chu1

  • 1From the Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan, Taiwan (YC-C, YC-C, WC-H); the Dementia Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan (YC-C, YC-C, WC-H); the Department of Medicine, Chang Gung University, Taoyuan, Taiwan (HH-T); the Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan (JJ-W); the Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University, Chang Gung Memorial Hospital, Linkou, Taiwan (JJ-W); the Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Keelung, Taiwan (JJ-W); the Healthy Ageing Research Center, Chang Gung University, Taoyuan, Taiwan (JJ-W); the Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan (JJ-W); the Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan (JD-L); the Department of Laboratory Medicine, Chang Gung Memorial Hospital at LinKou Taoyuan, Taiwan (PY-C); and the Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan (PY-C).

The Journal of Neuropsychiatry and Clinical Neurosciences
|October 25, 2017
PubMed
Summary

Periventricular white matter hyperintensities (WMH), particularly occipital caps, correlate with medial temporal lobe atrophy and Alzheimer's disease. These WMH predict cognitive decline, highlighting their clinical significance.

Keywords:
Alzheimer’s diseaseWhite matter hyperintensitymedial temporal lobe atrophymild cognitive impairment

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