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Updated: Feb 20, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Modelling diabetic nephropathy in mice.

Kengo Azushima^1,2, Susan B Gurley³, Thomas M Coffman^1,3

¹Cardiovascular and Metabolic Disorders Signature Research Program, Duke-NUS Medical School, 8 College Road, 169857 Singapore.

Nature Reviews. Nephrology

|October 25, 2017

Summary

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Developing better mouse models for diabetic nephropathy (DN) is crucial for finding new treatments. Current models have limitations, but improved genetic and systems biology approaches offer opportunities for advancing DN research.

Area of Science:

Nephrology
Diabetology
Translational Medicine

Background:

Diabetic nephropathy (DN) is a major cause of end-stage renal disease.
There is a critical need for improved animal models to study DN pathogenesis, identify drug targets, and test therapies.
Current mouse models often fail to fully replicate human DN features, hindering research progress.

Purpose of the Study:

To review the current status of mouse models for diabetic nephropathy.
To discuss the limitations of existing models and identify opportunities for improvement.
To emphasize the need for robust models that accurately reflect human DN phenotypes.

Main Methods:

Review of existing literature on mouse models for diabetic nephropathy.
Discussion of genetic manipulation and systems biology approaches.

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Assessment of Kidney Function in Mouse Models of Glomerular Disease

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Analysis of genomics and metabolomics data for model refinement.

Main Results:

Standard mouse models exhibit limited kidney abnormalities in diabetes.
Accelerated mouse models, using superimposed genetic stressors, better recapitulate key human DN features.
Further refinement of models is possible through systems biology and omics data.

Conclusions:

Improved mouse models are essential for advancing diabetic nephropathy research and drug discovery.
Future efforts should concentrate on creating models that faithfully reproduce the clinical and molecular aspects of human DN.
Enhanced models will facilitate a deeper understanding of DN and the development of effective treatments.