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Related Concept Videos

Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

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Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
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Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

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Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
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Related Experiment Video

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Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
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Solid-state mechanochemical ω-functionalization of poly(ethylene glycol).

Michael Y Malca1, Pierre-Olivier Ferko1, Tomislav Friščić1

  • 1Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, H3A 0B8, Canada.

Beilstein Journal of Organic Chemistry
|October 25, 2017
PubMed
Summary

This study introduces solvent-free mechanochemical methods for Poly(ethylene glycol) (PEG) functionalization. These sustainable procedures efficiently create various PEG derivatives without bulk solvents, offering a greener alternative for drug development and nanotechnology.

Keywords:
aminationbrominationcarboxylationmechanochemistrypoly(ethylene glycol)solid statethiolationtosylation

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Area of Science:

  • Polymer Chemistry
  • Green Chemistry
  • Nanotechnology

Background:

  • Poly(ethylene glycol) (PEG) is a versatile polymer utilized in chemical manufacturing, drug development, and nanotechnology.
  • PEG derivatives enhance drug solubility, reduce immunogenicity, and improve pharmacokinetic profiles of therapeutics and nanomaterials.

Purpose of the Study:

  • To develop novel mechanochemical procedures for PEG functionalization.
  • To offer a sustainable and solvent-free alternative to traditional solution-based PEG modification methods.

Main Methods:

  • Utilized mechanochemical techniques for PEG derivatization.
  • Performed solvent-free reactions to introduce tosyl, bromide, thiol, carboxylic acid, and amine functionalities onto PEG.

Main Results:

  • Achieved rapid and efficient PEG functionalization using mechanochemistry.
  • Obtained good to quantitative yields for various PEG derivatives.
  • Demonstrated no polymer chain oligomerization, confirming method versatility.

Conclusions:

  • Mechanochemical procedures provide a cleaner and more sustainable approach to PEG functionalization.
  • The developed methods are versatile, enabling the synthesis of diverse PEG derivatives without bulk solvents.
  • This advancement offers significant potential for greener chemical manufacturing and drug development.