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Immunohaematological reference values for HIV-negative healthy adults in Botswana
Madisa Mine1,2, Sikhulile Moyo2, Penny Stevens3
1National Health Laboratory, Gaborone, Botswana.
African Journal of Laboratory Medicine
|October 25, 2017
Summary
This study established new immunohaematological reference intervals for healthy adults in Botswana. These local values are crucial for accurate patient diagnosis and clinical trial management.
Area of Science:
- Clinical laboratory science
- Immunohaematology
- Public health
Background:
- Botswana's clinical labs historically used manufacturer-provided reference intervals.
- Lack of locally derived reference values may impact diagnostic accuracy.
Purpose of the Study:
- To determine reference intervals for normal immunohaematological values in healthy Botswana adults.
- Establish local benchmarks for key laboratory parameters.
Main Methods:
- Enrolled 261 healthy adults (126 males, 135 females) in southern Botswana.
- Measured immunological and haematological parameters.
- Calculated means, medians, and 2.5th/97.5th percentiles.
Main Results:
- Mean hemoglobin was lower in women (12.4 g/dL) than men (15.1 g/dL).
- Women's hemoglobin reference range (9.0-15.0 g/dL) differed from White populations but aligned with regional values.
- Established local reference intervals for immunohaematological values.
Conclusions:
- The determined reference intervals are vital for patient management in Botswana.
- Local values can inform clinical trial participant selection and adverse event monitoring.
- Provides essential data for improving healthcare diagnostics in the region.
