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Related Experiment Video

Updated: Feb 20, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
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Corticobasal degeneration: key emerging issues.

F Ali1, K A Josephs2

  • 1Department of Neurology, Mayo Clinic, Rochester, MN, USA. ali.farwa@mayo.edu.

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|October 25, 2017
PubMed
Summary
This summary is machine-generated.

Corticobasal degeneration (CBD) diagnosis remains challenging, despite advances in understanding its tau pathology. New neuroimaging techniques offer hope for improved diagnosis and treatment of this rare tauopathy.

Keywords:
AV-1451Corticobasal degenerationCorticobasal syndromeTau-PET

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Area of Science:

  • Neuroscience
  • Neuropathology
  • Clinical Neurology

Background:

  • Corticobasal degeneration (CBD) was first described in 1967, initially termed corticodentatonigral degeneration with neuronal achromasia.
  • Significant advancements have been made in understanding CBD's clinical features and underlying tau pathology.
  • Revised diagnostic criteria have been developed due to the challenges in clinical antemortem diagnosis of CBD.

Observation:

  • Accurate prevalence studies for CBD are limited because various clinical phenotypes can present with CBD pathology.
  • The pooled prevalence of frontotemporal lobar degeneration, progressive supranuclear palsy (PSP), and CBD is reported at 10.6 per 100,000.
  • CBD serves as a crucial model for studying proteinopathies (tauopathies) and evaluating tau-directed therapies.

Findings:

  • Identification of tau-specific ligands has recently advanced neuroimaging for tauopathies like CBD and PSP.
  • Despite progress, the clinical prediction of CBD pathology continues to be a significant challenge and an active area of research.
  • Emerging issues in CBD pathophysiology, genetics, and novel tau-ligand neuroimaging techniques are highlighted.

Implications:

  • Improved understanding of CBD pathophysiology can guide the development of targeted tau-directed therapies.
  • Advances in neuroimaging with tau ligands may lead to earlier and more accurate diagnosis of CBD.
  • Further research into CBD genetics and pathophysiology is essential for developing effective treatments for tauopathies.