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New data on chronic venous disease: a new place for Cyclo 3® Fort

Stavros K Kakkos1, Eliete Bouskela2, Arkadiusz Jawien3

  • 1Department of Vascular Surgery, University Hospital of Patras, Patras, Greece - kakkos@upatras.gr.

International Angiology : a Journal of the International Union of Angiology
|October 25, 2017
PubMed

Insights

The Ruscus, hesperidin methyl chalcone (HMC), and vitamin C combination (Cyclo 3® Fort) effectively treats chronic venous disease (CVD) symptoms. New guidelines should recommend this combination with a Grade 1A rating.

Area of Science:

  • Vascular Medicine
  • Pharmacology
  • Evidence-Based Medicine

Background:

  • Chronic venous disease (CVD) knowledge is advancing, necessitating updated management guidelines.
  • New data on therapies for CVD requires reevaluation of current recommendations.

Purpose of the Study:

  • To update recommendations for chronic venous disease (CVD) management.
  • To evaluate the efficacy of the Ruscus, hesperidin methyl chalcone (HMC), and vitamin C combination (Cyclo 3® Fort).

Main Methods:

  • A symposium reviewed recent developments on Cyclo 3® Fort.
  • In-vivo pharmacological experiments and a meta-analysis were presented.
  • Information on prospective 2018 CVD guidelines was shared.

Main Results:

  • The combination of Ruscus, HMC, and vitamin C demonstrated significant effects on pain, heaviness, swelling, tingling, ankle circumference, and global symptoms.
  • Evidence analysis supported a Grade A efficacy for the treatment.

Conclusions:

  • The Ruscus, HMC, and vitamin C combination (Cyclo 3® Fort) is highly effective for managing CVD symptoms.
  • A Grade 1A recommendation for this combination in future CVD guidelines is warranted.

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