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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Efficiently finding and using evidence to guide clinical practice and improve care
Mikhail Y Akbashev1, J Richard Pittman, Daniel D Dressler
1At Emory University School of Medicine in Atlanta, Ga., Mikhail Y. Akbashev is an assistant professor of medicine and J. Richard Pittman is an associate professor of medicine in the Division of General Medicine and Geriatrics and Department of Medicine, and Daniel D. Dressler is a professor of medicine in Division of Hospital Medicine and Department of Medicine. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Staying current with medical literature is hard. Systematic literature searching strategies improve the quality of evidence-based answers for better patient care.
Area of Science:
- Clinical Research
- Medical Informatics
- Evidence-Based Medicine
Background:
- Healthcare providers face challenges staying updated due to the vast volume of scientific literature.
- Unstructured literature searches or public search engines may provide low-quality or incorrect clinical answers.
- Suboptimal clinical care can result from relying on inaccurate information.
Purpose of the Study:
- To describe systematic strategies for primary literature searching.
- To enhance the quality of results obtained from literature searches.
- To provide an alternative to unstructured searching for clinical questions.
Main Methods:
- The article outlines systematic approaches to primary literature searching.
- Focus is placed on strategies that yield higher-quality results.
- Comparison is made to unstructured or public search engine methods.
Main Results:
- Systematic strategies yield higher-quality results compared to unstructured approaches.
- Improved literature searching can lead to more accurate clinical answers.
- Enhanced search methods support evidence-based patient care.
Conclusions:
- Systematic literature searching is crucial for effective evidence-based practice.
- Adopting structured search methods can mitigate risks associated with low-quality information.
- Improved information retrieval supports better patient outcomes.
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