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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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pV-Diagrams01:18

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The pV diagram, which is a graph of pressure versus volume of the gas under study, is helpful in describing certain aspects of the substance. When the substance behaves like an ideal gas, the ideal gas equation describes the relationship between its pressure and volume. On a pV diagram, it is common to plot an isotherm, which is a curve showing p as a function of V with the number of molecules and the temperature fixed. Then, for an ideal gas, the product of the pressure of the gas and its...
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Gene Duplication and Divergence02:37

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The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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CGDV: a webtool for circular visualization of genomics and transcriptomics data.

Vineet Jha1, Gulzar Singh1,2, Shiva Kumar1

  • 1Labs, Persistent Systems Limited, Pingala - Aryabhata, Erandwane, Pune, 411004, India.

BMC Genomics
|October 26, 2017
PubMed
Summary
This summary is machine-generated.

CGDV is a new webtool for automated visualization of genomics and transcriptomics data. It simplifies the generation of complex circular plots, aiding biologists and bioinformaticians in data interpretation.

Keywords:
Circular diagramGenomics and transcriptomics data visualizationVisualizationWeb circos

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Area of Science:

  • Genomics and Transcriptomics Data Analysis
  • Bioinformatics Tool Development
  • Computational Biology

Background:

  • Interpreting large-scale genomics and transcriptomics data is challenging.
  • Existing tools for automated data visualization are scarce and often require bioinformatics expertise.
  • Circular plots offer holistic data visualization but are complex to generate.

Purpose of the Study:

  • To develop a user-friendly webtool for automated visualization of diverse genomics and transcriptomics data.
  • To simplify the creation of circular plots for various data types and model organisms.
  • To provide a seamless visualization solution for biologists and bioinformaticians.

Main Methods:

  • Development of CGDV (Circos for Genomics and Transcriptomics Data Visualization) webtool.
  • Utilizes Circos for generating circular plots.
  • Accepts various data formats (vcf, bed, xls, etc.) and automates intermediate file generation.

Main Results:

  • CGDV enables seamless and automated visualization of large-scale genomics and transcriptomics data.
  • The tool generates circular plots from diverse analyzed data outputs.
  • CGDV is freely accessible online at https://cgdv-upload.persistent.co.in/cgdv/.

Conclusions:

  • CGDV facilitates biological insights through tailored circular plots for different data types.
  • The tool visualizes inter-relationships, gene fusions, expression patterns, and variations.
  • CGDV empowers biologists and bioinformaticians to visualize complex data effectively.