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Updated: Feb 20, 2026

A Murine Model of Carotid Aneurysm Formation
Published on: September 9, 2025
Comparative transcriptome analysis reveals involvement of TLR-2 signaling in the pathogenesis of intracranial
Jinghan Fan1, Lanbing Yu1, Jizong Zhao1
1Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, 6 Tiantan Xili, 100050 Beijing, China.
Abstract:
In this study, we collected and analyzed 15 aneurysmal and 17 superficial temporal artery (STA) specimens from 32 Chinese patients with intracranial aneurysm. Total RNA was extracted and reverse transcribed to cDNA, and genome-wide expression profiling was performed by using the Affymetrix Human Genome U133 Plus 2.0 Array which allows a total number of 38,500 genes to be analyzed at the same time. Real-time RT-PCR was performed to verify the expression level of 8 selected genes. We found significant up-regulation of the TLR-2 gene. This result suggests that TLR-2 plays a key role in the formation of intracranial aneurysm in a Chinese population. To our knowledge, this study is the first to use the Human Genome U133 Plus 2.0 Array to analyze the gene expression profiles in Chinese patients with intracranial aneurysm.
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